SNIPER (ABL) -049

• Target :

  Others|||SNIPERs|||Bcr-Abl

• Related Pathways :

  Angiogenesis|||Others|||Cytoskeletal Signaling|||PROTAC|||Tyrosine Kinase/Adaptors

• Bioactivity :

  SNIPER (ABL) -049, a compound that conjugates Imatinib (ABL inhibitor) with Bestatin (IAP ligand) through a linker, effectively reduces BCR-ABL protein levels, demonstrating a DC50 of 100 ?M[1].

• Smiles :

  CC1=CC=C(NC(C2=CC=C(CN3CCN(C(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC4=CC=CC=C4)N)=O)=O)=O)CC3)C=C2)=O)C=C1NC5=NC=CC(C6=CC=CN=C6)=N5

• Molecular Formula :

  C52H66N10O8

• Molecular Weight :

  959.14

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C