SNIPER (ABL) -015

• Target:

  Bcr-Abl|||Others|||SNIPERs

• Related Pathways:

  Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Others|||PROTAC

• Bioactivity:

  SNIPER (ABL) -015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5 ?M [1].

• Smiles:

  O=C (NCCOCCOCCOCCNC ([C@@H] (NC ([C@H]1N (C ([C@H] (C2CCCCC2) NC ([C@H] (C) NC) =O) =O) CCC1) =O) C (C3=CC=CC=C3) C4=CC=CC=C4) =O) C5=CC=CC (C6=NC=NC (NC7=CC=C (OC (F) (F) F) C=C7) =C6) =C5

• Molecular Formula:

  C58H70F3N9O9

• Molecular Weight:

  1094.23

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C