SNIPER (ABL) -058

• Description:

  SNIPER (ABL) -058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].

• UNSPSC:

  12352005

• Target:

  Bcr-Abl; SNIPERs

• Type:

  Reference compound

• Related Pathways:

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sniper-abl-058.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=C (NC (C2=CC=C (CN3CCN (C (COCCOCCOCCOC4=CC (C (C5=CSC ([C@H]6N (C ([C@H] (C7CCCCC7) NC ([C@H] (C) NC) =O) =O) CCC6) =N5) =O) =CC=C4) =O) CC3) C=C2) =O) C=C1NC8=NC=CC (C9=CC=CN=C9) =N8

• Molecular Formula:

  C62H75N11O9S

• Molecular Weight:

  1150.39

• References & Citations:

  [1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2222354-61-0