SNIPER (ABL) -047

• Target :

  Bcr-Abl|||SNIPERs|||Others

• Related Pathways :

  Others|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||PROTAC

• Bioactivity :

  SNIPER (ABL) -047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels, achieving a DC50 value of 2 ?M[1].

• Smiles :

  CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC(COCCOCCOCCNC([C@H](C(C6=CC=CC=C6)C7=CC=CC=C7)NC([C@H]8N(C([C@@H](NC([C@H](C)NC)=O)C9CCCCC9)=O)CCC8)=O)=O)=O)S5)C=C4)=CC=C3)=O)C=C2)CC1

• Molecular Formula :

  C67H82F3N11O9S

• Molecular Weight :

  1274.5

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C