SNIPER (ABL) -047

• Target:

  Bcr-Abl|||SNIPERs|||Others

• Related Pathways:

  Others|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||PROTAC

• Bioactivity:

  SNIPER (ABL) -047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels, achieving a DC50 value of 2 ?M[1].

• Smiles:

  CCN1CCN (CC2=C (C (F) (F) F) C=C (NC (C3=CC (C4=NC5=C (N=C (NC (COCCOCCOCCNC ([C@H] (C (C6=CC=CC=C6) C7=CC=CC=C7) NC ([C@H]8N (C ([C@@H] (NC ([C@H] (C) NC) =O) C9CCCCC9) =O) CCC8) =O) =O) =O) S5) C=C4) =CC=C3) =O) C=C2) CC1

• Molecular Formula:

  C67H82F3N11O9S

• Molecular Weight:

  1274.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C