SNIPER (ABL) -033

• Target:

  SNIPERs|||Others|||Bcr-Abl

• Related Pathways:

  Others|||Angiogenesis|||PROTAC|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors

• Bioactivity:

  SNIPER (ABL) -033, a compound that conjugates HG-7-85-01 (ABL inhibitor) to a LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 ?M[1].

• Smiles:

  C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(NC=5SC=6C(N5)=CC=C(N6)C7=CC(C(NC8=CC(C(F)(F)F)=C(CN9CCN(CC)CC9)C=C8)=O)=CC=C7)=O)=CC=C4)=CS3)[H]

• Molecular Formula:

  C61H73F3N10O9S2

• Molecular Weight:

  1211.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2222354-18-7