SNIPER (ABL) -047

CAT: 0804-HY-111863Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-111863Size:1 Each
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Description
SNIPER (ABL) -047, conjugating HG-7-85-01 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 2 μM[1].
UNSPSC
12352005
Target
Bcr-Abl; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-abl-047.html
Solubility
10 mM in DMSO
Smiles
CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC(COCCOCCOCCNC([C@H](C(C6=CC=CC=C6)C7=CC=CC=C7)NC([C@H]8N(C([C@@H](NC([C@H](C)NC)=O)C9CCCCC9)=O)CCC8)=O)=O)=O)S5)C=C4)=CC=C3)=O)C=C2)CC1
Molecular Formula
C67H82F3N11O9S
Molecular Weight
1274.50
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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