SNIPER (ABL) -033

• Description :

  SNIPER (ABL) -033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM (ABL inhibitor: HY-15814; ABL inhibitor activity control: HY-131178; E3 ligase ligand: HY-128808; linker: HY-130500; E3 ligase ligand + linker: HY-128819) [1].

• UNSPSC :

  12352005

• Target :

  Bcr-Abl; SNIPERs

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sniper-abl-033.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC(COCCOCCOCCOC6=CC(C(C7=CSC([C@H]8N(C([C@H](C9CCCCC9)NC([C@H](C)NC)=O)=O)CCC8)=N7)=O)=CC=C6)=O)S5)C=C4)=CC=C3)=O)C=C2)CC1

• Molecular Formula :

  C61H73F3N10O9S2

• Molecular Weight :

  1211.42

• References & Citations :

  [1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2222354-18-7]