STAT3-IN-31

• Description :

  STAT3-IN-31 (compound K2071) is a STATtic-derived STAT3 and mitotic inhibitor. STAT3-IN-31 blocks mitotic progression and affects the formation of mitotic spindles. STAT3-IN-31 also affects glioblastoma cell migration and inhibits cell proliferation in tumor spheroids. STAT3-IN-31 is also able to induce glioblastoma senescence, inhibit the growth of Temozolomide (HY-17364) -resistant cells and the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein MCP-1[1].

• UNSPSC :

  12352100

• Target :

  STAT

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Stem Cell/Wnt

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/stat3-in-31.html

• Smiles :

  COC1=CC=C(C=C1)CNC2=CC=C(C=CS3(=O)=O)C3=C2

• Molecular Formula :

  C16H15NO3S

• Molecular Weight :

  301.36

• References & Citations :

  [1]Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported