STAT3-IN-31

• Description:

  STAT3-IN-31 (compound K2071) is a STATtic-derived STAT3 and mitotic inhibitor. STAT3-IN-31 blocks mitotic progression and affects the formation of mitotic spindles. STAT3-IN-31 also affects glioblastoma cell migration and inhibits cell proliferation in tumor spheroids. STAT3-IN-31 is also able to induce glioblastoma senescence, inhibit the growth of Temozolomide (HY-17364) -resistant cells and the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein MCP-1[1].

• UNSPSC:

  12352100

• Target:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/stat3-in-31.html

• Smiles:

  COC1=CC=C (C=C1) CNC2=CC=C (C=CS3 (=O) =O) C3=C2

• Molecular Formula:

  C16H15NO3S

• Molecular Weight:

  301.36

• References & Citations:

  [1]Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported