STAT3-IN-49

• Description:

  STAT3-IN-49 (compound B16) is a potent and selective STAT3 inhibitor. STAT3-IN-49 binds to the SH2 domain of STAT3, thereby suppressing its phosphorylation and nuclear translocation. STAT3-IN-49 inhibits triple-negative breast cancer (TNBC) cell migration, invasion, and colony formation. STAT3-IN-49 inhibits tumor growth in an MDA-MB-231 xenograft mouse model. STAT3-IN-49 can be used for TNBC research[1].

• UNSPSC:

  12352005

• Target:

  STAT

• Related Pathways:

  JAK/STAT Signaling; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  O=C(C1=C2ON=C1C3=CC=C(OCCN4CCNCC4)C=C3)C5=C(C2=O)C=CO5

• Molecular Formula:

  C21H19N3O5

• Molecular Weight:

  393.39

• References & Citations:

  [1]Deng X, et al. Discovery of a novel napabucasin derivative B16 as a potent STAT3 inhibitor for the treatment of triple-negative breast cancer. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118329.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  STAT3