STAT3-IN-49

CAT: 0804-HY-179468Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179468Size:1 Each
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Description
STAT3-IN-49 (compound B16) is a potent and selective STAT3 inhibitor. STAT3-IN-49 binds to the SH2 domain of STAT3, thereby suppressing its phosphorylation and nuclear translocation. STAT3-IN-49 inhibits triple-negative breast cancer (TNBC) cell migration, invasion, and colony formation. STAT3-IN-49 inhibits tumor growth in an MDA-MB-231 xenograft mouse model. STAT3-IN-49 can be used for TNBC research[1].
UNSPSC
12352005
Target
STAT
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=C2ON=C1C3=CC=C(OCCN4CCNCC4)C=C3)C5=C(C2=O)C=CO5
Molecular Formula
C21H19N3O5
Molecular Weight
393.39
References & Citations
[1]Deng X, et al. Discovery of a novel napabucasin derivative B16 as a potent STAT3 inhibitor for the treatment of triple-negative breast cancer. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118329.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

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