BIO-7488

CAT: 0804-HY-162359-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-162359-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
BIO-7488 is an orally active, selective and blood-brain barrier permeable IRAK4 inhibitor, with an IC50 value of 0.5 nM. BIO-7488 inhibits the production of pro-inflammatory cytokines (IL-1β, TNFα, IL-6) and demonstrates anti-inflammatory effects in both LPS (HY-D1056) and distal hypoxic-middle cerebral artery occlusion (DH-MCAO) ischemic stroke model. BIO-7488 can be used for the study of neuroinflammatory-related diseases, particularly ischemic stroke[1].
CAS Number
[2573211-25-1]
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bio-7488.html
Purity
99.44
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1(C2)OCC2(C1)C3=CN4C(N=C(OC(C)C)C(C(NC5=C(N=CC(C)=C6)N6N=C5)=O)=C4)=N3
Molecular Formula
C23H25N7O3
Molecular Weight
447.49
References & Citations
[1]Ryan Evans, et al. The Discovery of 7-Isopropoxy-2- (1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl) -N- (6-methylpyrazolo[1,5-a]pyrimidin-3-yl) imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke. J.Med. Chem. 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4

Related Products

CatalogName
HY-15356-01BIO-acetoxime
HY-169329-01BIO-2007817
HY-106377BIO-11006
HY-14126-01BIO-1211
HY-158374BIO-8169
HY-103035-01BIO-32546
HY-115448-01Bio-AMS
HY-128867-01Bio-THZ1
HY-118810-01BIO-013077-01
HY-167387PLLA10000-PEG1000-BIO

Alternative Products

CatalogName
MF-0147348-01BIO-7488
1673-1BIO
B591713BIO 5192
MBS5766186BIO-32546
MBS5750996-BIO
BUP02613-01BIO-acetoxime
BA1417-10Bio-AMS
M14064-01BIO-7662
A17129-50BIO 50mg
MBS5773203BIO-1211

Popular Products