BIO-8169

• Description :

  BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu, u of 0.7[1].

• UNSPSC :

  12352005

• Target :

  IRAK

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/bio-8169.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(OC1=NC2=NC(C34COC(C3)(C4)C)=CN2C=C1C(NC5=CC=CN(C5=O)C6CC6)=O)C

• Molecular Formula :

  C24H27N5O4

• Molecular Weight :

  449.50

• References & Citations :

  [1]Pfaffenbach M, et al., Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation. J Med Chem. 2024 May 23;67 (10) :8383-8395.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IRAK4

• CAS Number :

  [2792153-06-9]