Bio-AMS

CAT: 0804-HY-115448-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-115448-01Size:5 mg
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Description
Bio-AMS is a potent bacterial biotin protein ligase inhibitor. Bio-AMS possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis[1][2].
CAS Number
[1393881-52-1]
Product Name Alternative
MK0364 (1R,2R)stereoisomer
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bio-ams.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]([C@@H]1O)[C@@H](O[C@@H]1CNS(NC(CCCC[C@H]2[C@](NC3=O)([H])[C@](N3)([H])CS2)=O)(=O)=O)N4C5=NC=NC(N)=C5N=C4
Molecular Formula
C20H29N9O7S2
Molecular Weight
571.63
References & Citations
[1]Bockman MR, Aldrich CC, et al. Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification. ACS Infect Dis. 2018 Jul 13;4 (7) :1102-1113.|[2]Tiwari D, et al. Targeting protein biotinylation enhances tuberculosis chemotherapy. Sci Transl Med. 2018 Apr 25;10 (438) :eaal1803.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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