Bio-AMS

• Description:

  Bio-AMS is a potent bacterial biotin protein ligase inhibitor. Bio-AMS possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis[1][2].

• Product Name Alternative:

  MK0364 (1R,2R)stereoisomer

• UNSPSC:

  12352005

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/bio-ams.html

• Purity:

  99.87

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@H]([C@@H]1O)[C@@H](O[C@@H]1CNS(NC(CCCC[C@H]2[C@](NC3=O)([H])[C@](N3)([H])CS2)=O)(=O)=O)N4C5=NC=NC(N)=C5N=C4

• Molecular Formula:

  C20H29N9O7S2

• Molecular Weight:

  571.63

• References & Citations:

  [1]Bockman MR, Aldrich CC, et al. Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification. ACS Infect Dis. 2018 Jul 13;4 (7) :1102-1113.|[2]Tiwari D, et al. Targeting protein biotinylation enhances tuberculosis chemotherapy. Sci Transl Med. 2018 Apr 25;10 (438) :eaal1803.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1393881-52-1]