Bio-THZ1

• Description :

  Bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM[1].

• UNSPSC :

  12352005

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bio-thz1.html

• Purity :

  98.06

• Solubility :

  DMSO : 120 mg/mL (ultrasonic)

• Smiles :

  O=C(NCCOCCOCCOCCNC(NCCCN(C)C/C=C/C(NC1=CC=C(C(NC2=CC=CC(NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)=C2)=O)C=C1)=O)=O)CCCC[C@@H]6SC[C@]([C@]6([H])N7)([H])NC7=O

• Molecular Formula :

  C52H65ClN12O8S

• Molecular Weight :

  1053.67

• References & Citations :

  [1]Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511 (7511) :616-20.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1604811-14-4]