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BIO-acetoxime

CAT: 0804-HY-15356-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15356-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.
CAS Number
667463-85-6
Product Name Alternative
BIA
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Apoptosis; GSK-3; HSV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BIO-acetoxime.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 14 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC2=C(C=CC(Br)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OC(C)=O
Molecular Formula
C18H12BrN3O3
Molecular Weight
398.21
Precautions
H302, H410
References & Citations
[1]Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10 (12) :1255-66.|[2]Hsu MJ, et al. Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells. Arch Virol. 2013 Jun;158 (6) :1287-96.|[3]Aourz N, et al. Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy. ACS Chem Neurosci. 2018 Nov 6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β; HSV-1

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