BIO-11006

• Description :

  BIO-11006 is a peptide that inhibits the function of the MARCKS protein. BIO-11006 attenuates LPS-induced neutrophil influx into the lungs, NF-κB activation, and expression of the proinflammatory cytokines KC and TNF-α. BIO-11006 also reverses disease progression in an LPS-induced mouse lung injury model. BIO-11006 is indicated for research on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) [1].

• UNSPSC :

  12352005

• Target :

  MARCKS

• Related Pathways :

  Cytoskeleton

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CC(NCC(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O

• Molecular Formula :

  C46H75N13O15

• Molecular Weight :

  1050.17

• References & Citations :

  [1]Yin Q, et al. An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2016 Nov;55 (5) :617-622.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  Phase 2

• CAS Number :

  [901117-03-1]