BIO-2007817

• UNSPSC Description:

  BIO-2007817 is a Parkin positive allosteric modulators (PAMs). BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase)autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC50: 0.17 μM)[1].

• Target Antigen:

  E1/E2/E3 Enzyme; PINK1/Parkin

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bio-2007817.html

• Smiles:

  CO[C@@H](C1=CN(N=C1)C)C(N2CC3=C(C=NN3C[C@H]2C(C)C)C4=CC=C(C=C4)C(N5CCCC6=C5C=CC=C6)=O)=O

• Molecular Weight:

  552.67

• References & Citations:

  [1]Shlevkov E, et al. Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. iScience. 2021 Dec 18;25(1):103650.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported