NS-062

• Description :

  NS-062 is an orally active, irreversible targeted covalent inhibitor for EGFR, and exhibits antiproliferative efficacy in drug-resistant double mutated H1975 cell with an IC50 of 0.19 μM. NS-062 exhibits antitumor efficacy in mouse H1975 xenograft model[1].

• UNSPSC :

  12352005

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ns-062.html

• Smiles :

  FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCCCN4CCOCC4)=C(NC([C@H]5CCCN5C(C(Cl)F)=O)=O)C=C32

• Molecular Formula :

  C28H30Cl2F2N6O4

• Molecular Weight :

  623.48

• References & Citations :

  [1]Shindo N, et al., Selective and reversible modification of kinase cysteines with chlorofluoroacetamides. Nat Chem Biol. 2019 Mar;15 (3) :250-258.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2226257-92-5]