NS-062

CAT: 0804-HY-123891Size: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-123891Size:1 Each

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Description

NS-062 is an orally active, irreversible targeted covalent inhibitor for EGFR, and exhibits antiproliferative efficacy in drug-resistant double mutated H1975 cell with an IC50 of 0.19 μM. NS-062 exhibits antitumor efficacy in mouse H1975 xenograft model[1].

CAS Number

[2226257-92-5]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ns-062.html

Smiles

FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCCCN4CCOCC4)=C(NC([C@H]5CCCN5C(C(Cl)F)=O)=O)C=C32

Molecular Formula

C28H30Cl2F2N6O4

Molecular Weight

623.48

References & Citations

[1]Shindo N, et al., Selective and reversible modification of kinase cysteines with chlorofluoroacetamides. Nat Chem Biol. 2019 Mar;15 (3) :250-258.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Catalog	Name
HY-129141-01	YKL-06-062
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HY-12379-01	NS-2028
HY-13913-01	NS-398
HY-19271-01	NS-2710
HY-13103-01	NS 11021
HY-101428-01	NS-638
HY-118646	NS-6740
HY-147383	NS-8
HY-12151-01	NS 1738

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Catalog	Name
T201773-01	NS-062
MBS131963	SNS-062
BUP06034-01	SY2-062
MBS3843031-01	SNIPER (ABL)-062
BA6250-5.1	YKL-06-062
M13419-01	SNIPER (ABL) -062
A18567-5	SNIPER (ABL) -062 5mg
A18567-10	SNIPER (ABL) -062 10mg
A18567-50	SNIPER (ABL) -062 50mg
366904	NS-398 (NS398, NS 398)

NS-062

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