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NS-6740

CAT: 0804-HY-118646Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-118646Size:1 Each
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Description
NS-6740 is a 7 nAChRs partial agonist with a Ki of 1.1 nM. NS-6740 is also an effective modulator of the cholinergic anti-inflammatory pathway. NS-6740 switched the signaling mode of 7 in a channel-independent manner, which reduces synaptic function. NS-6740 can induce the desensitization state of 7 nAChRs. NS-6740 can result in the generation of robust nAChR-mediated currents. NS-6740 reduces lipopolysaccharide-induced TNF-α release from microglia. NS-6740 can be studied in research on inflammatory and neurological disease such as chronic and neuropathic pain[1][2][3].
CAS Number
[753500-02-6]
UNSPSC
12352005
Target
NAChR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CC=C(O1)C2=CC=CC(C(F)(F)F)=C2)N3CCN4CCC3CC4
Molecular Formula
C19H19F3N2O2
Molecular Weight
364.36
References & Citations
[1]Sasaki, T., et al., (2024) . Modulation of Ca2+ oscillation following ischemia and nicotinic acetylcholine receptors in primary cortical neurons by high-throughput analysis. Scientific reports, 14 (1), 27667.|[2]Thomsen MS, et al., The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J Neuroimmunol. 2012 Oct 15;251 (1-2) :65-72. |[3]Papke RL, et al., NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity. Neurosci Lett. 2018 Jun 11;677:6-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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