NS-2028

CAT: 0804-HY-12379-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-12379-01Size:5 mg

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Description

NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity[1]. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM[1]. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1) -elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM[1]. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM) [1]. NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability[2].

CAS Number

[204326-43-2]

UNSPSC

12352005

Target

Guanylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ns-2028.html

Purity

99.58

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1ON=C2COC3=CC=C(Br)C=C3N21

Molecular Formula

C9H5BrN2O3

Molecular Weight

269.05

References & Citations

[1]Olesen SP, et al. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br J Pharmacol. 1998 Jan;123 (2) :299-309.|[2]Morbidelli L, et al. The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298 (3) :R824-32.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Alternative Products

Catalog	Name
S1769	NS-2028
4517/10	NS 2028
A21643-5	NS-2028 5mg
A21643-50	NS-2028 50mg
A21643-100	NS-2028 100mg
A21643-10	NS-2028 10mg
A21643-25	NS-2028 25mg
A21643-1	NS-2028 1mg
A21643-200	NS-2028 200mg
A21643-10mM-D	NS-2028 10mM * 1mL in DMSO

NS-2028

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