NS 11021

CAT: 0804-HY-13103-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13103-01Size:5 mg
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Description
NS 11021 is a potent and specific Ca2+-activated big-conductance K+ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].
CAS Number
[956014-19-0]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ns-11021.html
Concentration
10mM
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NN=NN3
Molecular Formula
C16H9BrF6N6S
Molecular Weight
511.24
Precautions
H302, H312, H332
References & Citations
[1]Bo Hjorth Bentzen, et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007 Oct;72 (4) :1033-44|[2] Cagil Coskun, et al. BK channel openers NS1619 and NS11021 reverse hydrogen peroxide-induced membrane potential changes in skeletal muscle. J Recept Signal Transduct Res. 2020 Oct;40 (5) :449-455.|[3]Stephen Shrum, et al. Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage-Induced Mitochondrial Injury In Vitro. Biomolecules. 2019 Dec 4;9 (12) :825.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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