NS-8

• Description:

  NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H312-H332

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/ns-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(C2=C(F)C=CC=C2)NC(N)=C1C#N

• Molecular Formula:

  C12H10FN3

• Molecular Weight:

  215.23

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations:

  [1]M Tanaka, et al. A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity. BJU Int. 2003 Dec;92 (9) :1031-6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  [186033-14-7]