NCC-149

• Description :

  NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1].

• Product Name Alternative :

  L-APB (monohydrate), D-APB; D-2-Amino-4-phosphonobutyric acid, L-APB, l-Bicuculline (methobromide), 2-APH; 2-Amino-7-phosphonoheptanoic acid

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ncc-149.html

• Purity :

  99.29

• Solubility :

  DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(NO)C1=CC=CC(C2=CN(CSC3=CC=CC=C3)N=N2)=C1

• Molecular Formula :

  C16H14N4O2S

• Molecular Weight :

  326.38

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Katayama S, et al. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498 (1) :45-51.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC8

• CAS Number :

  [1316652-41-1]