NCC-149

• Description:

  NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1].

• Product Name Alternative:

  L-APB (monohydrate), D-APB; D-2-Amino-4-phosphonobutyric acid, L-APB, l-Bicuculline (methobromide), 2-APH; 2-Amino-7-phosphonoheptanoic acid

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ncc-149.html

• Purity:

  99.29

• Solubility:

  DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (NO) C1=CC=CC (C2=CN (CSC3=CC=CC=C3) N=N2) =C1

• Molecular Formula:

  C16H14N4O2S

• Molecular Weight:

  326.38

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Katayama S, et al. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498 (1) :45-51.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC8

• CAS Number:

  1316652-41-1