XD2-149

• Description:

  XD2-149 is a PROTAC targeting STAT3. XD2-149 consists of PROTAC target protein ligand Napabucasin (HY-13919) (red part), E3 ligase Thalidomide (HY-14658) (black part), and linker NH2-C5-Azacyclohexane-N-Boc (HY-159572) (blue part) . The E3 ligase + linker conjugate is Thalidomide-NH-C5-azacyclohexane-N-Boc (HY-159571), and the active control of the target protein ligand is Thalidomide acid (HY-159573) [1].

• UNSPSC:

  12352005

• Target:

  PROTACs; STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/xd2-149.html

• Smiles:

  O=C (C1=CC2=C (C (C3=C (C2=O) C=CC=C3) =O) O1) NCCN4CCC (CCCCCNC5=CC=CC (C (N6C7C (NC (CC7) =O) =O) =O) =C5C6=O) CC4

• Molecular Formula:

  C38H39N5O8

• Molecular Weight:

  693.74

• References & Citations:

  [1]Hanafi M, et al. Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91. J Med Chem. 2021 Feb 11;64 (3) :1626-1648.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2710221-08-0