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JBJ-07-149

CAT: 0804-HY-151048-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-151048-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JBJ-07-149 is an inhibitor for EGFRL858R/T790M with an IC50 of 1.1 nM. JBJ-07-149 inhibits the proliferation of cell Ba/F3 with IC50 of 4.9 μM and 0.148 μM, without and with presence of Cetuximab. JBJ-07-149 can be used as ligand for target protein in synthesis of DDC-01-163 (HY-139997).
CAS Number
2140807-58-3
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jbj-07-149.html
Smiles
O=C1C2=CC(C3=CC=C(N4CCNCC4)N=C3)=CC=C2CN1C(C5=CC=CC=C5)C(NC6=NC=CS6)=O
Molecular Formula
C28H26N6O2S
Molecular Weight
510.61
References & Citations
[1]Jang J, et al., Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations. Angew Chem Int Ed Engl. 2020 Aug 17;59 (34) :14481-14489.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

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