XD2-149

• Target :

  PROTACs|||STAT

• Related Pathways :

  Stem Cells|||JAK/STAT signaling|||PROTAC

• Bioactivity :

  XD2-149 is a PROTAC compound designed to target STAT3. It is composed of the PROTAC target protein ligand Napabucasin, the E3 ligase Thalidomide, and the linker NH2-C5-Azacyclohexane-N-Boc. The conjugate of the E3 ligase and linker is Thalidomide-NH-C5-azacyclohexane-N-Boc, with Thalidomideacid serving as the active comparator for the target protein ligand.

• Smiles :

  O=C(NCCN1CCC(CC1)CCCCCNC2=CC=CC=3C(=O)N(C(=O)C23)C4C(=O)NC(=O)CC4)C=5OC=6C(=O)C=7C=CC=CC7C(=O)C6C5

• Molecular Formula :

  C38H39N5O8

• Molecular Weight :

  693.75

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2710221-08-0