MG 149

CAT: 0804-HY-15887-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15887-01Size:1 mg
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Description
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM) ; little potent for PCAF and p300 (IC50 >200 uM) . MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG 149 can induce mitochondrial depolarization and promote PINK1 dependent mitochondrial clearance. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease[1][2][3].
CAS Number
[1243583-85-8]
Product Name Alternative
Tip60 HAT inhibitor
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain; Histone Acetyltransferase; PINK1/Parkin
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mg-149.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2
Molecular Formula
C22H28O3
Molecular Weight
340.46
References & Citations
[1]Ghizzoni M, et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47 (1) :337-44.|[2]de Talhouët C, et al. KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy. Sci Rep. 2024 May 22;14 (1) :11721. |[3]Wang Y, et al. TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release. Clin Exp Hypertens. 2023 Dec 31;45 (1) :2259130.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; PINK1; TIP60

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