MG 149

• Description:

  MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM) ; little potent for PCAF and p300 (IC50 >200 uM) . MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG 149 can induce mitochondrial depolarization and promote PINK1 dependent mitochondrial clearance. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease[1][2][3].

• Product Name Alternative:

  Tip60 HAT inhibitor

• UNSPSC:

  12352005

• Target:

  Apoptosis; Epigenetic Reader Domain; Histone Acetyltransferase; PINK1/Parkin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Epigenetics; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/mg-149.html

• Purity:

  99.60

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2

• Molecular Formula:

  C22H28O3

• Molecular Weight:

  340.46

• References & Citations:

  [1]Ghizzoni M, et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47 (1) :337-44.|[2]de Talhouët C, et al. KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy. Sci Rep. 2024 May 22;14 (1) :11721. |[3]Wang Y, et al. TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release. Clin Exp Hypertens. 2023 Dec 31;45 (1) :2259130.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CBP/p300; PINK1; TIP60

• CAS Number:

  [1243583-85-8]