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SJF-1521

CAT: 0804-HY-131865-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131865-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research. (Pink: EGFR ligand ; Black: Linker (HY-128804) ; Blue: VHL Ligand (HY-125845) ).
CAS Number
2230821-40-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sjf-1521.html
Purity
99.65
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOC(C=C4)=CC=C4C5=CC(C(NC6=CC(Cl)=C(C=C6)OCC7=CC(F)=CC=C7)=NC=N8)=C8C=C5)=O
Molecular Formula
C57H61ClFN7O9S
Molecular Weight
1074.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25 (1) :67-77.e3.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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