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SJFα

CAT: 0804-HY-114404-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114404-01Size:5 mg
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Description
SJFα is a selective p38α PROTAC degrader with a DC50 of 7.16 nM and Dmax of 97.4%. SJFα is far less effective at degrading p38δ (DC50 = 299 nM) . SJFαcan be used for the research of cancer, such as breast cancer[1]. (Structure Note: Pink: p38α ligand (HY-45124) ; Blue: VHL ligand (HY-125845) )
CAS Number
[2254609-27-1]
UNSPSC
12352005
Target
P38 MAPK; PROTACs
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SJF_alpha_.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1
Molecular Formula
C59H67F2N7O11S
Molecular Weight
1120.27
References & Citations
[1]Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10 (1) :131.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α; p38δ; von Hippel-Lindau (VHL)

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