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SJF-0661

CAT: 0804-HY-157512-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157512-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand with no targeted degradation ability and can be used as a control reagent for the VHL ubiquitin ligase ligand. SJF-0661 is a variant obtained by inverting the stereocenter of the key hydroxyproline group in the VHL ligand[1].
CAS Number
2413035-43-3
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sjf-0661.html
Purity
99.2
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C(NS(CCC)(=O)=O)=CC=C1F)F)C2=CNC3=NC=C(C4=CC=C(N5CCN(CC5)CC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@@H](C6)O)C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)C=C4)C=C23
Molecular Formula
C51H57F2N9O7S2
Molecular Weight
1010.18
References & Citations
[1]Alabi S, et al. Mutant-selective degradation by BRAF-targeting PROTACs. Nat Commun. 2021 Feb 10;12 (1) :920.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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