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SJF-0628

CAT: 0804-HY-136420-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136420-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJF-0628 is a RAF PROTAC degrader. SJF-0628 induces targeted degradation of BRAF in various cancer cell lines (colorectal cancer cell lines (Colo-205, LS-411N, HT-29, RKO) and triple-negative breast cancer cell line DU-4475). SJF-0628 decreases pMEK and pErk levels in DU-4475 cells. SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of colorectal cancer and triple-negative breast cancer. (Pink: RAF ligand , Blue: VHL Ligand (HY-125845), Black: Linker (HY-B0912) ).
CAS Number
2413035-41-1
UNSPSC
12352005
Target
Apoptosis; PROTACs; Raf
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sjf-0628.html
Purity
99.90
Solubility
DMSO : 160 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC=C(C4=CN=C(NC=C5C(C6=C(F)C=CC(NS(=O)(CCC)=O)=C6F)=O)C5=C4)C=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Molecular Formula
C51H57F2N9O7S2
Molecular Weight
1010.18
References & Citations
[1]Chapdelaine AG, et al. The Targeted Degradation of BRAF V600E Reveals the Mechanisms of Resistance to BRAF-Targeted Treatments in Colorectal Cancer Cells. Cancers (Basel) . 2023 Dec 12;15 (24) :5805.|[2]Alabi S, et al. Mutant-selective degradation by BRAF-targeting PROTACs. Nat Commun. 2021 Feb 10;12 (1) :920.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; von Hippel-Lindau (VHL)

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