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SJF-1528

CAT: 0804-HY-131864-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-131864-01Size:1 mg
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Description
SJF-1528 (PROTAC 1) is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 also degrades HER2. SJF-1528 promotes ubiquitination and degradation of EGFR and can be used in breast cancer research (Pink: ligand for target protein (HY-159047) ; Black: linker Tos-PEG2-CH2-Boc (HY-130532) ; Blue: ligand for E3 ligase (S, R, S) -AHPC (HY-125845) ) [1].
CAS Number
[2230821-38-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sjf-1528.html
Purity
99.71
Solubility
DMSO : 103.06 mg/mL (ultrasonic; warming)
Smiles
O=C([C@H]1N(C([C@@H](NC(COCCOCCOC2=CC=C(C3=CC4=C(NC5=CC=C(OCC6=CC=CC(F)=C6)C(Cl)=C5)N=CN=C4C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Molecular Formula
C55H57ClFN7O8S
Molecular Weight
1030.60
Precautions
H315, H319, H320
References & Citations
[1]Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25 (1) :67-77.e3.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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