SJF-8240

CAT: 0804-HY-123961-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-123961-01Size:1 mg
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Description
SJF-8240 (PROTAC 7) is a proteolysis targeting chimera (PROTAC) degrader. SJF-8240 induces polyubiquitination of c-Met and inhibits the proliferation of GTL16 cells (IC50=66.7 nM) [1].
CAS Number
[2230821-68-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
C-Met/HGFR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sjf-8240.html
Purity
99.33
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=CC=C(C=C1)NC(C2(C(NC3=CC(F)=C(C=C3)OC4=CC=NC5=C4C=C(C(OCCCOCCCOCCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=C5)OC)=O)CC2)=O
Molecular Formula
C58H65F2N7O11S
Molecular Weight
1106.24
Precautions
H302, H315, H319
References & Citations
[1]Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25 (1) :67-77.e3.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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