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STAT3-IN-39

CAT: 0804-HY-171038Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171038Size:1 Each
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Description
STAT3-IN-39 (compound 10K) is an orally active STAT3 inhibitor that exhibits excellent inhibitory activity against STAT3 phosphorylation, with an IC50 of 0.47 μM in NIH-3T3 cells. STAT3-IN-39 inhibits the TGF-β1-induced fibrotic response and blocks the epithelial-mesenchymal transition in A549. STAT3-IN-39 can be utilized in research related to idiopathic pulmonary fibrosis[1].
CAS Number
3037596-35-0
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/stat3-in-39.html
Smiles
O=C(C1=CC2=CC=CC=C2S1(=O)=O)N3CCN(CC4=CC(F)=C(F)C=C4F)CC3
Molecular Formula
C20H17F3N2O3S
Molecular Weight
422.42
References & Citations
[1]Wang Y, et al. Discovery of the novel Benzo[b]thiophene 1,1-dioxide derivatives as a potent STAT3 inhibitor against idiopathic pulmonary fibrosis. Eur J Med Chem. 2023 Jan 15;246:114953.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

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