BRD-K20733377

• Description :

  BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide (HY-13629) -induced IMR-90 senescent cell with an IC50 of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model[1].

• UNSPSC :

  12352005

• Target :

  Bcl-2 Family

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/brd-k20733377.html

• Concentration :

  10mM

• Purity :

  99.50

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C1=CC=C(C=C1)C2=CC=CC=C2)NC3=CC=C(C=C3)S(=O)(NC4=NC=CC=N4)=O

• Molecular Formula :

  C23H18N4O3S

• Molecular Weight :

  430.48

• References & Citations :

  [1]Wong F, et al., Discovering small-molecule senolytics with deep neural networks. Nat Aging. 2023 Jun;3 (6) :734-750.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [452350-43-5]