BRD 4354

CAT: 0804-HY-112719-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112719-01Size:5 mg
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Description
BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.
CAS Number
[315698-07-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BRD_4354.html
Purity
98.10
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4
Molecular Formula
C21H23ClN4O
Molecular Weight
382.89
Precautions
H315, H319, H335
References & Citations
[1]Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11 (7) :1844-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC5; HDAC9

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