BRD 4354

• Description :

  BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  HDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/BRD_4354.html

• Purity :

  98.10

• Solubility :

  DMSO : 12.5 mg/mL (ultrasonic)

• Smiles :

  OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4

• Molecular Formula :

  C21H23ClN4O

• Molecular Weight :

  382.89

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11 (7) :1844-51.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC5; HDAC9

• CAS Number :

  [315698-07-8]