BRD-4592

• Description :

  BRD-4592 is an allosteric inhibitor targeting Mycobacterium tuberculosis tryptophan synthase (TrpAB) . BRD-4592 binds at the α-β-subunit interface of TrpAB, with an IC50 of 70.9 nM for the α-subunit and 22.6 nM for the β-subunit[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Smiles :

  N#C[C@H]1[C@H](C2=CC=C(C3=C(C=CC=C3)F)C=C2)[C@@H](N1)CO

• Molecular Formula :

  C17H15FN2O

• Molecular Weight :

  282.31

• References & Citations :

  [1]Samantha Wellington, et al. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat Chem Biol. 2017 Sep;13 (9) :943-950.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2119598-24-0]