BRD-SF2

CAT: 0804-HY-161368Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-161368Size:1 Each
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Description
BRD-SF2 is a BRD4-targeted PROTAC degrader (DC50: 17.2 μM) (Blue: VHL ligand, black: linker, pink: BRD4 ligand) [1].
CAS Number
[3050690-26-8]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd-sf2.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C)C=C(C2=NC(C=C(C3CCN(C(COCCOCCOCCNC(C[C@H](NC([C@H]4N(C([C@@H](C5=CC(C)=NO5)C(C)C)=O)C[C@H](S(=O)(F)=O)C4)=O)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)CC3)C=C8)=C8N2C(COC)COC)C=C1C
Molecular Formula
C59H76FN9O13S2
Molecular Weight
1202.42
References & Citations
[1]Shah RR, et al. Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. J Med Chem. 2024 Mar 28;67 (6) :4641-4654.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4

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