BRD-SF2

• Description :

  BRD-SF2 is a BRD4-targeted PROTAC degrader (DC50: 17.2 μM) (Blue: VHL ligand, black: linker, pink: BRD4 ligand) [1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/brd-sf2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C)C=C(C2=NC(C=C(C3CCN(C(COCCOCCOCCNC(C[C@H](NC([C@H]4N(C([C@@H](C5=CC(C)=NO5)C(C)C)=O)C[C@H](S(=O)(F)=O)C4)=O)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)CC3)C=C8)=C8N2C(COC)COC)C=C1C

• Molecular Formula :

  C59H76FN9O13S2

• Molecular Weight :

  1202.42

• References & Citations :

  [1]Shah RR, et al. Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. J Med Chem. 2024 Mar 28;67 (6) :4641-4654.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  BRD4

• CAS Number :

  [3050690-26-8]