RegisterLogin

BRD-810

CAT: 0804-HY-162858-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-162858-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
BRD-810 is a potent and selective MCL1 inhibitor with a Kd of 0.3 nM. BRD-810 can specifically block the BH3 binding groove of MCL1, while having little effect on other anti-apoptotic proteins (such as Bcl-2, Bcl-xL) . BRD-810 effectively destroys the MCL1-BAK complex (IC50 = 1.2 nM) in cancer cells, rapidly activates Caspase and induces cell apoptosis. BRD-810 can be used in the research of various cancers such as hematological tumors and solid tumors[1].
CAS Number
[2329719-65-3]
UNSPSC
12352101
Target
Apoptosis; Bcl-2 Family; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd-810.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(N1CCCCO[C@H](CCN2CCOCC2)C3=NN(C)C(CC)=C43)=C(CCCOC5=C6C(C=C(F)C=C6)=CC=C5)C7=C1C4=C(Cl)C=C7
Molecular Formula
C39H44ClFN4O5
Molecular Weight
703.24
References & Citations
[1]Rauh U, et al. BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models. Nat Cancer. 2024 Oct;5 (10) :1479-1493.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Mcl-1

Related Products

CatalogName
HY-100719-01BRD-6929
HY-114268-01BRD-K98645985
HY-123610BRD-7880
HY-122016ABRD-4592
HY-172348BRD-9327
HY-169267BRD-K44839765
HY-169265-01BRD-K20733377
HY-112719-01BRD 4354
HY-116455BRD-9526
HY-161368BRD-SF2

Alternative Products

CatalogName
C15124BRD-810
M11547-01BRD-4770
T69692-01BRD-K25923209
T209544-01BRD-SF2
T10604-01BRD-IN-3
T10605-01BRD-K98645985
T10603-01BRD-6929
MBS133429BRD K4477
MBS3602999BRD-IN-17
B3293-5BRD-5529

Popular Products