BRD-6929

• UNSPSC Description:

  BRD-6929 is a?potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with?Ki?of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research[3].

• Target Antigen:

  HDAC; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Infection; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/brd-6929.html

• Purity:

  99.04

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3

• Molecular Weight:

  351.42

• References & Citations:

  [1]Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147|[2]Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323.|[3]Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9(3):268-273.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  849234-64-6