BRD-6929

• Description :

  BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research[3].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  HDAC; HIV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Infection; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/brd-6929.html

• Concentration :

  10mM

• Purity :

  99.01

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3

• Molecular Formula :

  C19H17N3O2S

• Molecular Weight :

  351.42

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147|[2]Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8 (8) :e71323.|[3]Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9 (3) :268-273.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC2; HDAC3; HIV-1

• CAS Number :

  [849234-64-6]