Antitumor agent-180

• UNSPSC Description:

  Antitumor agent-180 (Compound 13a) is an inhibitor for BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B). Antitumor agent-180 inhibits the proliferation of ccRCC cell Caki-1 with IC50 of 2.047 µM. Antitumor agent-180 induces necrosis and apoptosis in Caki-1[1].

• Target Antigen:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-180.html

• Smiles:

  CN(CC1)CCN1C2=CC=C(NC3=C(C)C=NC(NC4=CC=C(C(NC5=CC=C(N6CCN(C)CC6)C=C5)=O)C=C4)=N3)C=C2

• Molecular Weight:

  591.75

• References & Citations:

  [1]Bouzian Y, et al., Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma. Bioorg Chem. 2024 Jul 6;151:107597.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4