22-SLF

• Description :

  22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM. 22-SLF interacts with C227 and C228 in FBXO22 to induce a ternary complex between FKBP12 and FBXO22, and degrades FKBP12 in a FBXO22-dependent manner. 22-SLF can be used for fundamental cancer research as a probe to study the FBXO22 degradation pathway. (Pink: FKBP12 ligand (HY-114872) ; Black: Linker (HY-163821) ; Blue: FBXO22 ligand (HY-163826) ) [1].

• UNSPSC :

  12352005

• Target :

  FKBP; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/22-slf.html

• Purity :

  95.72

• Smiles :

  CCC(C)(C(C(N1CCCC[C@H]1C(O[C@@H](C2=CC(OCC(NCCCOCCOCCOCCCN(C(C3=NC4=C(S3)C=CC=C4)C(NCC5=CC=CC=C5)=O)C(CCl)=O)=O)=CC=C2)CCC6=CC=C(C(OC)=C6)OC)=O)=O)=O)C

• Molecular Formula :

  C60H76ClN5O13S

• Molecular Weight :

  1142.79

• References & Citations :

  [1]Basu AA, et al., A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation. Nat Chem Biol. 2024 Jul 4.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  FKBP12