22-SLF

• UNSPSC Description:

  22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM in a FBXO22 dependent manner. 22-SLF degrades other endogenous proteins, such as BRD4 and EML4-ALK fusion protein.(Pink: Ligand for target protein SLF (HY-114872); Black: Linker (HY-163821); Blue: Ligand for E3 ligase (HY-163826))[1].

• Target Antigen:

  FKBP; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/22-slf.html

• Smiles:

  CCC(C)(C(C(N1CCCC[C@H]1C(O[C@@H](C2=CC(OCC(NCCCOCCOCCOCCCN(C(C3=NC4=C(S3)C=CC=C4)C(NCC5=CC=CC=C5)=O)C(CCl)=O)=O)=CC=C2)CCC6=CC=C(C(OC)=C6)OC)=O)=O)=O)C

• Molecular Weight:

  1142.79

• References & Citations:

  [1]Basu AA, et al., A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation. Nat Chem Biol. 2024 Jul 4.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported