SLF (TFA)

• Description :

  SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3].

• UNSPSC :

  12352005

• Target :

  FKBP; Ligands for Target Protein for PROTAC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/slf-tfa.html

• Purity :

  99.58

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(C(F)(F)F)=O.CCC(C)(C)C(C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(N)=CC=C2)CCC3=CC(OC)=C(C=C3)OC)=O)=O)=O

• Molecular Formula :

  C32H41F3N2O8

• Molecular Weight :

  638.67

• References & Citations :

  [1]Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13 (5) :486-95.|[2]Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.|[3]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15 (7) :737-746.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  FKBP51

• CAS Number :

  [2378802-47-0]