SLF (TFA)

• UNSPSC Description:

  SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3].

• Target Antigen:

  FKBP; Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/slf-tfa.html

• Purity:

  99.58

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC(C(F)(F)F)=O.CCC(C)(C)C(C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(N)=CC=C2)CCC3=CC(OC)=C(C=C3)OC)=O)=O)=O

• Molecular Weight:

  638.67

• References & Citations:

  [1]Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.|[2]Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95.|[3]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  2378802-47-0