10-SLF

CAT: 0931-MF-0053917-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0053917-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2765058-89-5
Target
FKBP|||PROTACs
Related Pathways
PROTAC|||Immunology/Inflammation|||Apoptosis|||Autophagy
Bioactivity
10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.
Smiles
C(N(CCCOCCOCCOCCCNC(COC1=CC([C@H](OC(=O)[C@H]2N(C(C(C(CC)(C)C)=O)=O)CCCC2)CCC3=CC(OC)=C(OC)C=C3)=CC=C1)=O)C(CCl)=O)(C(NCC4=CC=CC=C4)=O)C5=CC=C(Cl)C=C5
Molecular Formula
C59H76Cl2N4O13
Molecular Weight
1120.16
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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