10-SLF

• Target:

  FKBP|||PROTACs

• Related Pathways:

  PROTAC|||Immunology/Inflammation|||Apoptosis|||Autophagy

• Bioactivity:

  10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.

• Smiles:

  C(N(CCCOCCOCCOCCCNC(COC1=CC([C@H](OC(=O)[C@H]2N(C(C(C(CC)(C)C)=O)=O)CCCC2)CCC3=CC(OC)=C(OC)C=C3)=CC=C1)=O)C(CCl)=O)(C(NCC4=CC=CC=C4)=O)C5=CC=C(Cl)C=C5

• Molecular Formula:

  C59H76Cl2N4O13

• Molecular Weight:

  1120.16

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2765058-89-5