SLF

• Description :

  SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC[1][2][3].

• Product Name Alternative :

  eFT508, eFT508 (hydrochloride)

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  FKBP; Ligands for Target Protein for PROTAC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/slf.html

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(N)=C2)CCC3=CC=C(OC)C(OC)=C3

• Molecular Formula :

  C30H40N2O6

• Molecular Weight :

  524.65

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.|[2]Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13 (5) :486-95.|[3]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15 (7) :737-746.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  FKBP51

• CAS Number :

  [195513-96-3]