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Ferroptosis-IN-22

CAT: 0804-HY-175869Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175869Size:1 mg
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Description
Ferroptosis-IN-22 is a selective ferroptosis inhibitor by targeting NCOA4 and disrupting its interaction with ferritin with an EC50 of 520 nM and a Kd of 0.78 μM. Ferroptosis-IN-22 has a strong inhibitory activity against ferroptosis induced by multiple ferroptosis inducers (RSL3 , Erastin (HY-15763), ML210 (HY-100003), FIN56 (HY-103087) ), but does not inhibit necrosis induced by H2O2 or apoptosis induced by STS (HY-15141). Ferroptosis-IN-22 effectively ameliorates Concanavalin A (HY-P2149) -induced acute liver injury. Ferroptosis-IN-22 can be used for the study of ferroptosis-related diseases[1].
CAS Number
3096878-87-1
UNSPSC
12352005
Target
Ferroptosis
Related Pathways
Apoptosis
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Purity
99.97
Smiles
CC(C)(C)C1=C(C=C2OC3=NC(C4=CC=CC=C4)=CC(C5=CC=CC=C5)=C3C2=C1)O
Molecular Formula
C27H23NO2
Molecular Weight
393.48
References & Citations
[1]Zhang J, et al. Identification of Benzofuro[2,3-b]pyridine Pseudonatural Product as a Novel Class of Ferritinophagy Inhibitors that Potently Suppress Ferroptosis. J Med Chem. 2025 Sep 11;68 (17) :18703-18726.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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