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KB03-SLF

CAT: 0804-HY-147196Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147196Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KB03-SLF (compound 6) is an electrophilic PROTAC degrader that binds to DCAF16 to degrade the nuclear protein FKBP12. KB03-SLF can be used in cancer research[1]. (Pink: Ligand for target protein SLF ; Black: Linker (HY-W040168) ; Blue: Ligand for E3 ligase (HY-169968) ).
CAS Number
2384184-42-1
UNSPSC
12352005
Target
FKBP; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kb03-slf.html
Smiles
O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@@H](C2=CC(NC(CCOCCOCCNC(CCNC(C3=CC(NC(CCl)=O)=CC(C(F)(F)F)=C3)=O)=O)=O)=CC=C2)CCC4=CC(OC)=C(C=C4)OC
Molecular Formula
C50H63ClF3N5O12
Molecular Weight
1018.51
References & Citations
[1]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16[J]. Nature chemical biology, 2019, 15 (7) : 737-746.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12

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