10-SLF

• Description :

  10-SLF is a PROTAC FKBP12 degrader. 10-SLF induces a ternary complex between FKBP12 and FBXW7-R465C, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF selectively reduces FKBP12 levels in cells expressing FBXW7-R465C. Pink: FKBP12 ligand (HY-170988) ; Black: linker (HY-W004640) ; Blue: E3 ligase ligand[1].

• UNSPSC :

  12352005

• Target :

  FKBP; PROTACs

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@H](CCC2=CC(OC)=C(C=C2)OC)C3=CC=CC(OCC(NCCCOCCOCCOCCCN(C(CCl)=O)C(C4=CC=C(C=C4)Cl)C(NCC5=CC=CC=C5)=O)=O)=C3

• Molecular Formula :

  C59H76Cl2N4O13

• Molecular Weight :

  1120.16

• References & Citations :

  [1]Basu AA, et al. Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation. bioRxiv [Preprint]. 2024 Dec 4:2024.12.03.626601.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  FKBP12

• CAS Number :

  [2765058-89-5]