HDAC3-IN-4

HDAC3-IN-4

• CAS Number: 2988762-46-3
• UNSPSC Description: HDAC3-IN-4 is a selective and orally active HDAC3 inhibitor with an IC50 of 89 nM. HDAC3-IN-4 induces the degradation of PD-L1 by regulating cathepsin B (CTSB) in the lysosomes, with a DC50 of 5.7 μM. HDAC3-IN-4 shows better selectivity for HDAC3 over HDAC1, HDAC6, HDAC7, and HDAC8[1].
• Target Antigen: HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hdac3-in-4.html
• Smiles: O=C(C1=NC=C(CNC2=CC=CC=C2)S1)NCC3=CC=C(C(NNCCC)=O)C=C3
• Molecular Weight: 423.53
• References & Citations: [1]Zhiqiang Sun, et al. Discovery of Novel HDAC3 Inhibitors with PD-L1 Downregulating/Degrading and Antitumor Immune Effects. J Med Chem. 2024 Jul 20.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported