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HDAC3-IN-4

CAT: 931-T89627-01Size: 10 mgDry Ice: NoHazardous: No
10 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2988762-46-3
Bioactivity
HDAC3-IN-4 is a selective and orally active inhibitor of HDAC3, boasting an IC50 of 89 nM. It induces the degradation of PD-L1 by modulating cathepsin B (CTSB) in lysosomes, with a DC50 of 5.7 ?M. Compared to HDAC1, HDAC6, HDAC7, and HDAC8, HDAC3-IN-4 demonstrates superior selectivity for HDAC3.
Smiles
O=C(NCC1=CC=C(C=C1)C(=O)NNCCC)C2=NC=C(S2)CNC=3C=CC=CC3
Molecular Formula
C22H25N5O2S
Molecular Weight
423.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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