Products for Research Use Only
RegisterLogin

HDAC3/6-IN-2

CAT: 0804-HY-133147Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-133147Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].
CAS Number
2417510-17-7
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac3-6-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(N2CCN(C([C@](CC[C@]3(C)CC[C@@]4(C)[C@]5(C)CCC6C(C)(C)C(C(C#N)=C[C@]6(C)C57)=O)(C)C[C@@]3([H])C4=CC7=O)=O)CC2)C=C1)CCCCCCC(NO)=O
Molecular Formula
C49H67N5O6
Molecular Weight
822.09
References & Citations
[1]Huang M, Xie X, Gong P, et al. A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects. Eur J Med Chem. 2020;188:111991.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6

Related Products

CatalogName
HY-172133HDAC3-IN-6
HY-156096-01HDAC3-IN-2
HY-172891CDK9/HDAC1/HDAC3-IN-1
HY-161154HDAC3-IN-3
HY-117374-01HDAC3-IN-1
HY-172601HDAC3-IN-7
HY-123295-01HDAC3-IN-T247
HY-159172HDAC3-IN-4
HY-162769HDAC3-IN-5
HY-162781HDAC1/6-IN-2

Alternative Products

CatalogName
MBS5816034HDAC3/6-IN-2
T205688-01HDAC3-IN-6
MBS5821375HDAC3-IN-2
482592HDAC3
144650HDAC3 (RPD3-2, SMAP45)
143189HDAC3 (RPD3-2 SMAP45)
036478HDAC3, CT (HDAC3, Histone deacetylase 3, RPD3-2, SMAP45)

Popular Products